@media (min-width: 1400px) {

  .container-xxl,
  .container-xl,
  .container-lg,
  .container-md,
  .container-sm,
  .container {
    max-width: 1175px;
  }
}

.row {
  margin-right: -15px;
  margin-left: -15px;
}


/*globally css*/
h1,
h2,
h3,
h4,
h5,
h6 {
  color: #003366;
  line-height: 100%;
}

b,
strong {
  font-weight: bold;
}

a {
  text-decoration: none !important;
}

h1 {
  font-size: 45px;
  font-weight: bold;
  line-height: 1.07;
  margin-bottom: 24px;
}

.text-align-center {
  text-align: center;
}

h2 {
  font-size: 35px;
  line-height: 40px;
  font-weight: 300;
  color: #003366;
  margin-bottom: 16px;
}

h3 {
  font-size: 23px;
  line-height: 32px;
  font-weight: 600;
  color: #003366;
}

h4 {
  font-size: 21px;
  line-height: 28px;
}

h5 {
  font-size: 18px;
  line-height: 25px;
}

h6 {
  font-size: 16px;
  line-height: 21px;
}

a {
  color: #00254b;
  cursor: pointer;
  transition: all 0.3s !important;
}

a:hover {
  transition: all 0.3s !important;
}

.header_top.clearfix nav.main_menu ul li.menu-item.narrow a {
  color: #00254b;
  cursor: pointer;
  transition: all 0.3s !important;
}

.header_top.clearfix nav.main_menu ul li.menu-item.narrow a:hover {
  transition: all 0.3s !important;
}

p a {
  font-weight: 600;
  text-decoration: underline;
}

p:not(:last-child) {
  margin: 0 0 10px;
}

@media (max-width: 1000px) {

  h1+h2,
  h2+p {
    margin-bottom: 16px !important;
  }
}


p.mobile-eyebrow {
  display: none;
}

a:hover {
  text-decoration: none;
  color: #ff9900;
}

img {
  max-width: 100%;
  height: auto;
}

sup {
  vertical-align: super;
  line-height: 0;
  font-size: 10px;
}

body {
  font-stretch: normal;
  font-style: normal;
  font-family: "Source Sans Pro", sans-serif;
  font-size: 17px;
  font-weight: 400;
  line-height: 24px;
  letter-spacing: normal;
  color: #333;
}

p:last-child {
  margin: 0;
}

.h-100 {
  height: auto !important;
  min-height: 100% !important;
}

h1,
h2,
h3,
h4,
h5,
h6 {
  color: #003366;
  line-height: 1.1;
}

h1 {
  font-size: 45px;
  font-weight: bold;
  line-height: 1.07;
  margin-bottom: 24px;
}

.h2-style {
  margin-top: 0;
  margin-bottom: 10px;
  font-size: 35px;
  font-weight: 300;
  color: #036;
  line-height: 40px;
  text-transform: capitalize;
  letter-spacing: 0;
}

/* fonts  */
.font-14 {
  font-size: 14px;
  line-height: 1.5;
}

.font-20.font-20.font-20 {
  font-size: 20px;
  line-height: 1.6;
}

.font24 {
  font-size: 24px;
}

.font-35 {
  font-size: 35px;
}

.fw-light {
  font-weight: 300;
}

/* spaciing  */
.mt-0 {
  margin-top: 0 !important;
}

/* p.font-20:not(:last-child) {
	margin-bottom: 24px !important;
} */
.margin-bottom-64px,
p.font-20:not(:last-child).margin-bottom-64px {
  margin-bottom: 64px !important;
}

.margin-bottom-48px {
  margin-bottom: 48px !important;
}

.margin-bottom-32px {
  margin-bottom: 32px !important;
}

.margin-bottom-24px {
  margin-bottom: 24px !important;
}

.margin-bottom-17px {
  margin-bottom: 17px !important;
}

.margin-bottom-16px {
  margin-bottom: 16px !important;
}

.margin-bottom-0px {
  margin-bottom: 0px !important;
}

.margin-top-64px {
  margin-top: 64px !important;
}

.margin-top-48px {
  margin-top: 48px !important;
}

.margin-top-32px {
  margin-top: 32px !important;
}

.margin-top-24px {
  margin-top: 24px !important;
}

.margin-top-17px {
  margin-top: 17px !important;
}

.margin-top-16px {
  margin-top: 16px !important;
}

.margin-top-0px {
  margin-top: 0px !important;
}

.mb-16.mb-16.mb-16 {
  margin-bottom: 16px;
}

.mb-8 {
  margin-bottom: 8px;
}

@media (min-width: 768px) {
  .mt-sm-0 {
    margin-top: 0 !important;
  }

  .mb-sm-0 {
    margin-bottom: 0 !important;
  }

  .mt-sm-64 {
    margin-top: 32px !important;
  }

  .mb-sm-64 {
    margin-bottom: 32px !important;
  }

  .mt-sm-64 {
    margin-top: 64px !important;
  }

  .mb-sm-64 {
    margin-bottom: 64px !important;
  }
}

.ps-32 {
  padding-left: 32px;
  padding-right: 32px;
}

.ms-32 {
  margin-left: 32px;
  margin-right: 32px;
}

.row.equal {
  display: flex;
  flex-wrap: wrap;
}

/* Background colors  */
.bg-blue {
  background-color: #00254b;
  color: white;
}

.bg-blue strong {
  color: #b9d9eb;
}

.bg-blue h2,
.bg-blue h3 {
  color: white;
}

.bg-blue .button-more:hover {
  border-color: #b9d9eb !important;
}

@media(max-width:767px) {
  .mobile-margin-top-0 {
    margin-top: 0 !important;
  }
}

@media(min-width:991px) {
  .desk-margin-bottom-64px {
    margin-bottom: 64px !important;
  }

  .desk-margin-top-32px {
    margin-top: 32px;
  }
}

.ptb-64 {
  padding: 64px 0 !important;
}

.mtb-64 {
  margin: 64px auto !important;
}

.mb-16 {
  margin-bottom: 16px !important;
}

.mt-16 {
  margin-top: 16px !important;
}

.mb-24 {
  margin-bottom: 24px !important;
}

.mt-24 {
  margin-top: 24px !important;
}

.mb-32 {
  margin-bottom: 32px !important;
}

.mt-32 {
  margin-top: 32px !important;
}

.mb-48 {
  margin-bottom: 48px !important;
}

.mt-48 {
  margin-top: 48px !important;
}

.mb-64 {
  margin-bottom: 64px !important;
}

.mt-64 {
  margin-top: 64px !important;
}

.pb-16 {
  padding-bottom: 16px !important;
}

.pt-16 {
  padding-top: 16px !important;
}

.pb-24 {
  padding-bottom: 24px !important;
}

.pt-24 {
  padding-top: 24px !important;
}

.pb-32 {
  padding-bottom: 32px !important;
}

.pt-32 {
  padding-top: 32px !important;
}

.pb-48 {
  padding-bottom: 48px !important;
}

.pt-48 {
  padding-top: 48px !important;
}

.pb-64 {
  padding-bottom: 64px !important;
}

.pt-64 {
  padding-top: 64px !important;
}

main>.container-fluid.p-0 {
  overflow: hidden;
}



.mobile-eyebrow>span {
  text-transform: capitalize;
}


.region.region-content {
  padding: 0 !important;
}

.hide {
  display: none !important;
}

.no-wrap {
  white-space: nowrap;
}

@media (min-width: 1001px) {
  .alnylam__basic-search-block #search-open-btn {
    margin-top: -1px;
    margin-right: 5px;
  }
}


/*************************/
@media(min-width:1600px) {
  .owl-item .slide .images-con .desktop-show img {
    width: 100%;
  }
}


/****** Main slide ******/
.slide {
  position: relative;
}

.slide .inner-con {
  position: absolute;
  top: 50%;
  left: 50%;
  transform: translate(-50%, -50%);
  width: 100%;
  display: flex;
  justify-content: start;
  flex-direction: column;
}

.slide .mobile-show {
  display: none;
}

.main-title {
  max-width: max-content;
}

.slide .main-title h2 {
  font-family: Source Sans Pro;
  font-size: 60px;
  font-weight: 300;
  line-height: 66px;
  text-align: left;
  color: #FFF;
  padding-left: 135px;
  margin-top: 0;
  margin-bottom: 0;
  padding-top: 48px;
  position: relative;
}

.slide .main-title h2::before {
  content: "";
  top: 0;
  width: 100%;
  position: absolute;
  height: 24px;
  background-image: url("/sites/default/files/img/dna-lines-slide.svg");
  left: 0;
}

.slide .content-desc {
  margin-left: 135px;
}

.slide .content-desc h3 {
  font-family: Source Sans Pro;
  font-size: 60px;
  font-weight: 700;
  line-height: 66px;
  text-align: left;
  margin: 6px 0 24px;
  color: #3DD5AE;
}

.slide .content-desc p {
  font-family: Source Sans Pro;
  font-size: 21px;
  font-weight: 400;
  line-height: 32px;
  text-align: left;
  color: #FFF;
  max-width: 540px;
}

.slide .buttons-con {
  margin-top: 32px;
  /* display: none; */
}

.slide .buttons-con a {
  padding: 8px 32px 10px 32px;
  border-radius: 5px;
  border: 2px solid #3DD5AE;
  font-family: Source Sans Pro;
  font-size: 20px;
  font-weight: 700;
  line-height: 24px;
  text-align: left;
  text-decoration-skip-ink: none;
  color: #3DD5AE;
  display: inline-block;
  background-color: #003366;
}

.slide .buttons-con a:hover {
  color: #FFF;
  background-color: #3DD5AE;
}



@media(min-width:992px) and (max-width:1200px) {
  .slide .main-title h2 {
    padding-left: 32px;
  }

  .slide .content-desc {
    margin-right: 32px;
  }

  .new-news::before {
    background-position: right;
  }
}

@media(min-width:768px) and (max-width:992px) {
  .slide .main-title h2 {
    font-size: 32px;
    line-height: normal;
    padding-left: 32px;
  }

  .new-news::before {
    background-position: right;
  }

  .slide .content-desc {
    margin-left: 32px;
  }

  .slide .content-desc h3 {
    font-size: 32px;
    margin: 6px 0 16px;
    line-height: normal;
  }

  .slide .content-desc p {
    font-size: 20px;
    line-height: normal;
  }

  .slide .buttons-con {
    margin-top: 32px;
  }

  .new-news {
    margin-top: 64px;
  }
}

@media(max-width:767px) {
  .slide .inner-con {
    flex-direction: column;
    top: unset;
    left: 0;
    transform: unset;
    bottom: 53px;
  }

  .slide .main-title h2 {
    padding-left: 32px;
  }

  .slide .content-desc {
    margin-right: 32px;
  }

  .slide .main-title h2 {
    font-size: 36px;
    line-height: normal;
    margin: 0;
    padding: 28px 0 0 32px;
  }

  .slide .main-title h2::before {
    bottom: unset;
    top: 0;
    background-image: url("/sites/default/files/img/dna-lines-slide-mobile.svg");
    background-repeat: no-repeat;
    height: 17px;
  }

  .slide .content-desc {
    margin: 0 32px 0px;
  }

  .slide .content-desc h3 {
    font-family: Source Sans Pro;
    font-size: 36px;
    font-weight: 700;
    line-height: normal;
    text-align: left;
    margin: 0 0 16px;
    color: #3DD5AE;
  }

  .slide .content-desc p {
    font-size: 20px;
    line-height: 28px;
    max-width: 100%;
  }

  .slide .buttons-con {
    margin-top: 8px;
  }

  .slide .buttons-con a {
    font-size: 10px;
    line-height: normal;
    padding: 4px 10px;
    height: 24px;
  }

  .slide .mobile-show {
    display: block !important;
  }

  .slide .desktop-show {
    display: none;
  }
}

.owl-wrapper.owl-origin .progress-bar {
  width: 0%;
  transition-delay: 0s;
  transition-duration: 0s !important;
}

.slide .main-title h2 {
  overflow: hidden;
}

.owl-wrapper.owl-origin .slide .main-title h2::before {
  left: -200px;
  transition-duration: 0s;
}

.slide .main-title h2::before {
  left: 0;
  transition-duration: 1s;
}

.progress-bar {
  background-color: #3DD5AE;
  width: 100%;
  height: 12px;
  position: relative;
  margin-top: -12px;
  float: none;
  transition-delay: 1s;
  transition-duration: 3.5s;
}

@media(max-width:767px) {
  .progress-bar {
    height: 13px;
    margin-top: -13px;
  }
}

/**************************************/
#clp-html-content-background .content-wrapper {
  padding: 64px 48px;
}

#clp-html-content-background h2 {
  font-size: 32px;
  font-weight: 900;
  line-height: 32px;
}

section.whole-full-with-video-area {
  position: relative;
}

.full-width-video-title img {
  position: absolute;
  top: 50%;
  left: 50%;
  height: 100px;
  transform: translate(-50%, -50%);
}

.full-width-video-title h2 {
  color: #fff;
  font-weight: 600;
  position: absolute;
  left: 25%;
  top: 47%;
  width: 387px;
  font-size: 49px;
  line-height: 1.25;
  transform: translate(-28%, -50%);
}

/****************/
/* SIMPLE PAGE BANNER WITH TEXT */
#simple-banner-with-text-wrapper {
  overflow: hidden;
  background-size: cover;
  background-position-y: -50px;
  background-repeat: no-repeat;
  height: 704px;
  position: relative;
}

.mobile-upper-text {
  display: none;
}

#simple-banner-with-text-wrapper h1,
#simple-banner-with-text-wrapper h2,
#simple-banner-with-text-wrapper p {
  color: #fff;
}

#simple-banner-with-text-wrapper .quote {
  position: absolute;
  bottom: 40px;
  left: 0px;
  right: 0px;
  text-align: right;
  font-size: 14px;
  font-weight: 400;
  padding: 10px;
  text-shadow: 1px 1px 5px #000;
}

#simple-banner-with-text-wrapper .text-wrapper .upper-text {
  max-width: 575px;
  background-color: rgba(26, 58, 103, 0);
  padding: 0 0 0 40px;
  position: absolute;
  left: 155px;
  top: calc(50% - 35px);
  transform: translateY(-50%);
}

/* CLP FULL BLEED BG */
#clp-full-bleed-bg {
  overflow: hidden;
  background-size: cover;
  clear: both;
}

#clp-full-bleed-bg .text-wrapper h1,
#clp-full-bleed-bg .text-wrapper h2,
#clp-full-bleed-bg .text-wrapper h3,
#clp-full-bleed-bg .text-wrapper p {
  color: #ffffff;
}

#clp-full-bleed-bg .text-wrapper {
  background-color: rgba(26, 58, 103, 0.7);
  margin: 100px auto !important;
  padding: 30px;
  text-align: center;
}

#clp-full-bleed-bg .text-wrapper a {
  color: #189cd7;
}

/* CLP LEFT TEXT IMG */
#clp-left-img-text {
  padding: 64px 0;
  overflow: hidden;
}

#clp-left-img-text .img-text-wrapper .img-box {
  width: 64%;
  margin-right: 2%;
  float: left;
}

#clp-left-img-text .img-text-wrapper .text-box {
  width: 33%;
  float: right;
}

/* CLP 3 Column Video Text */
#clp-3-column-video-text {
  padding: 64px;
  margin-top: -30px !important;
  overflow: hidden;
}

#clp-3-column-video-text .text {
  width: 33%;
  float: left;
  margin-top: -30px;
  padding: 0 15px;
}

#clp-3-column-video-text .video {
  width: 66%;
  float: right;
}

#clp-3-column-video-text h2 {
  margin-top: 20px;
}

/* CLP Column Description Thumbnail */
#clp-video-description-thubmnail {
  width: 32%;
  float: left;
  margin-right: 1%;
}

#clp-video-description-thubmnail .video-content .image-box {
  position: relative;
}

#clp-video-description-thubmnail .video-content .three-column-video-play-button img {
  height: 48px;
  width: 48px;
  position: absolute;
  top: 40%;
  left: 40%;
  /* transform: translate(-1%,-10%); */
}

#clp-video-description-thubmnail .video-content .description {
  margin-top: 24px;
}

/* CLP 2 COLUMN VIDEO */
#clp-2-column-text-video {
  width: 100%;
  display: flex;
}

#clp-2-column-video-text {
  padding: 64px;
  margin-top: -30px !important;
  overflow: hidden;
}

#clp-2-column-video-text .text {
  width: 48%;
  float: left;
  margin-top: -30px;
  padding: 0 15px;
}

#clp-2-column-video-text .video {
  width: 52%;
  float: right;
}

#clp-2-column-video-text #clp-video-description-thubmnail {
  margin-left: 5%;
  width: 43%;
  margin-right: 0;
}

/* CLP HTML CONTENTN WITH BACKGROUND */
#clp-html-content-background .content-wrapper {
  padding: 64px 48px;
}

/* CLP BANNER OVERLAY */
#clp-banner-overlay .banner-text-wrapper {
  padding: 56px 100px 64px 100px;
  overflow: hidden;
  background-color: #ffffff;
  margin-top: -30px !important;
}

/* CLP FULL BLEED BG */
#clp-full-bleed-bg {
  overflow: hidden;
  background-size: cover;
  clear: both;
}

#clp-full-bleed-bg .text-wrapper h1,
#clp-full-bleed-bg .text-wrapper h2,
#clp-full-bleed-bg .text-wrapper h3,
#clp-full-bleed-bg .text-wrapper p {
  color: #ffffff;
}

#clp-full-bleed-bg .text-wrapper {
  background-color: rgba(26, 58, 103, 0.7);
  margin: 100px auto !important;
  padding: 30px;
  text-align: center;
}

#clp-full-bleed-bg .text-wrapper a {
  color: #189cd7;
}

@media(min-width:991px) {
  #clp-full-bleed-bg .text-wrapper h2 {
    font-size: 45px;
    font-weight: bold;
    line-height: 1.07;
    margin-bottom: 24px;
  }
}

@media only screen and (max-width: 1000px) {

  /* clp-full-bleed-bg */
  #clp-full-bleed-bg {
    padding: 0 10px;
  }

  #clp-full-bleed-bg .text-wrapper {
    width: 100% !important;
    margin: 65px auto !important;
    padding: 8px 8px 20px;
  }

  #clp-full-bleed-bg .text-wrapper h1,
  #clp-full-bleed-bg .text-wrapper h2 {
    font-size: 30px;
    line-height: 32px;
  }

  #clp-full-bleed-bg h1+h2,
  #clp-full-bleed-bg h2+p {
    margin-bottom: 16px !important;
  }

  #clp-full-bleed-bg p:last-child {
    margin-bottom: 0;
  }

  #clp-full-bleed-bg .text-wrapper p a {
    font-size: 18px;
    font-weight: bold;
    text-decoration: none;
    color: #ff9900;
  }
}

/*************/
.drop_down .second {
  display: none !important;
}

#onetrust-consent-sdk {
  z-index: 9999999999999;
}

#clp-full-bleed-bg ul {
  margin: 0px 0px 30px;
  padding-left: 1.5em;
  list-style: disc;
}

#clp-full-bleed-bg ul li::marker {
  color: #ff9900;
}

#clp-full-bleed-bg ul li {
  color: #ffffff;
}

.global-link {
  padding-right: 20px;
}

.global-link::after {
  content: "";
  background: url(/sites/default/files/img/icon-button-link-out.png);
  background-size: cover;
  width: 12px;
  height: 12px;
  display: block;
  position: absolute;
  top: calc(50% - 6px);
  right: 0px;
}

.global-link .leaving-site {
  color: #00254b;
  cursor: pointer;
  font-weight: 600;
}

@media (min-width: 1001px) {
  .header_inner_right {
    position: unset;
    flex: unset !important;
  }

  nav.main_menu>ul#menu-main-menu .menu-item.narrow:last-child {
    display: none;
  }
}


@media (max-width: 1000px) {
  .global-link {
    display: none;
  }
}

main>.container-fluid.p-0 .row.g-0 {
  margin: 0;
}

/****/
.whole-full-with-video-area,
#clp-3-column-video-text {
  display: none;
}

#clp-html-content-background.blue-section .content-wrapper {
  padding: 64px 0 !important;
}

.clp-callingout-h1-cta-component {
  display: flex;
  color: #FFF;
  gap: 30px;
  align-items: center;
}

.clp-callingout-h1-cta-component .col-sm-7 {
  width: calc(58.33333333% - 15px);
}

.clp-callingout-h1-cta-component .col-sm-5 {
  width: calc(41.66666667% - 15px);
}

#clp-html-content-background.blue-section .heading {
  font-size: 45px;
  font-weight: bold;
  line-height: 1.14;
  color: #ffffff;
  text-transform: uppercase;
  margin: 0;
  padding: 0;
}

.clp-callingout-h1-cta-short-description p {
  color: #FFF;
  max-width: 630px;
}

.button-container {
  display: flex;
  justify-content: end;
  align-items: center;
}

.clp-callingout-h1-cta-link .button-container a {
  background: #fff;
  border: 4px solid #bbd9eb;
  padding: 15px 40px;
  font-size: 18px;
  font-weight: 600;
  color: #00245b;
  max-height: 72px;
  text-transform: uppercase;
  line-height: 35px;
  box-sizing: border-box;
  display: inline-block;
}

.clp-callingout-h1-cta-link .button-container a:hover {
  background: #00254b;
  color: #fff !important;
  border: 4px solid #f4f9fc;
}

.clp-html-background-desc h5 {
  font-size: 18px;
  line-height: 25px;
  color: #003366;
  font-family: inherit;
  font-weight: 500;
  text-transform: none;
  letter-spacing: normal;
  margin: 0;
}

.clp-html-background-desc h5 + h5 {
  margin-top: 10px;
}

/****************************/
/* SIMPLE PAGE BANNER WITH TEXT */
#simple-banner-with-text-wrapper {
    overflow: hidden;
    background-size: cover;
    background-position-y: -50px;
    background-repeat: no-repeat;
    height: 704px;
    position: relative;
}

.mobile-upper-text {
    display: none;
}

#simple-banner-with-text-wrapper h1,
#simple-banner-with-text-wrapper h2,
#simple-banner-with-text-wrapper p {
    color: #fff;
}

#simple-banner-with-text-wrapper .quote {
    position: absolute;
    bottom: 40px;
    left: 0px;
    right: 0px;
    text-align: right;
    font-size: 14px;
    font-weight: 400;
    padding: 10px;
    text-shadow: 1px 1px 5px #000;
}

#simple-banner-with-text-wrapper .text-wrapper .upper-text {
    max-width: 575px;
    background-color: rgba(26, 58, 103, 0);
    padding: 0 0 0 40px;
    position: absolute;
    left: 155px;
    top: calc(50% - 35px);
    transform: translateY(-50%);
}